Coagulation Cascade

coagulation cascade  The process of blood coagulation leads to haemostasis, prevention of bleeding or haemorrhage Blood clotting involves activation and aggregation of The coagulation cascade is useful to understand as it provides a framework for interpreting basic coagulation tests -the PT and APTT

Triggered by the exposure of tissue factor in the damaged blood vessel wall to the circulating factor VII Final Common Pathway The Coagulation Cascade  The levels of activated Protein C and ProteinS increase at the site of coagulation This increase

Coagulation cascade: Secondary hemostasis Initiation of thrombin generation: Subendothelial tissue factor on fibroblasts (and smooth Once coagulation is triggered by one of these pathways, clotting factors are sequentially activated in an amplification cascade, ultimately